Global deaths from Staphylococcus aureus–associated lower respiratory tract infections (LRTIs) in older adults nearly tripled from 1990 to 2021, according to a study published yesterday in BMC Infectious Diseases.
Using data from the MICROBE (Multidisciplinary Investigation of Clinical Research Outcomes and Burden Estimates) database, Chinese researchers analyzed estimates on deaths and disability-adjusted life years (DALYs) associated with 22 pathogens and 84 drug-pathogen combinations across 204 countries. They focused specifically on S aureus, including deaths and DALYs attributable to methicillin-resistant S aureus (MRSA).
S aureus colonizes skin and mucosal surfaces, and the researchers note that older adults are particularly vulnerable to S aureus LRTIs because of the deterioration of the immune system that accompanies aging, the prevalence of comorbidities, and frequent contact with healthcare facilities. MRSA compounds the problem by limiting treatment options.
“The global spread of antimicrobial resistance (AMR) in S. aureus, especially methicillin resistance (MRSA), represents a critical public health issue,” they wrote.
By: Chris Dall, MA University of Minnesota